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Overview | Gene
delivery controlled by redox potential gradients | Layer-by-layer
DNA films for gene delivery | Stimulus-controlled
drug delivery from nanoporous inorganic nanoparticles
Layer-by-layer DNA films for gene delivery
Localized delivery of therapeutic genes represents an attractive approach that could find use in a variety of biomedical applications, including implantable materials and biomedical devices and tissue engineering. A promising method for local gene delivery relies on layer-by-layer (LbL) thin films assembled from DNA and polycations. The LbL method, in which polyelectrolytes of opposite charges are placed one layer at a time alternately on top of each other, allows to easily assemble and then disassemble molecular components in a programmable fashion.
Collaborators
Prof. Guangzhao Mao
Representative Publications
J. Blacklock, H. Handa, D. Soundara Manickam, G. Mao, A. Mukhopadhy, D. Oupicky. "Disassembly of Layer-by-Layer Films of Plasmid DNA and Reducible TAT Polypeptide." Biomaterials, 2007, 28, 117-124. (Abstract)
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