Overview  |  Gene delivery controlled by redox potential gradients  |  Layer-by-layer DNA films for gene delivery | Stimulus-controlled drug delivery from nanoporous inorganic nanoparticles

Localized delivery of therapeutic genes represents an attractive approach that could find use in a variety of biomedical applications, including implantable materials and biomedical devices and tissue engineering. A promising method for local gene delivery relies on layer-by-layer (LbL) thin films assembled from DNA and polycations. The LbL method, in which polyelectrolytes of opposite charges are placed one layer at a time alternately on top of each other, allows to easily assemble and then disassemble molecular components in a programmable fashion.

Collaborators

Prof. Guangzhao Mao

Representative Publications

J. Blacklock, H. Handa, D. Soundara Manickam, G. Mao, A. Mukhopadhy, D. Oupicky. "Disassembly of Layer-by-Layer Films of Plasmid DNA and Reducible TAT Polypeptide." Biomaterials, 2007, 28, 117-124. (Abstract)