Overview  |  Gene delivery controlled by redox potential gradients  |  Layer-by-layer DNA films for gene delivery | Stimulus-controlled drug delivery from nanoporous inorganic nanoparticles

Localized delivery of therapeutic genes represents an attractive approach that could find use in a variety of biomedical applications, including implantable materials and biomedical devices and tissue engineering. A promising method for local gene delivery relies on layer-by-layer (LbL) thin films assembled from DNA and polycations. The LbL method, in which polyelectrolytes of opposite charges are placed one layer at a time alternately on top of each other, allows to easily assemble and then disassemble molecular components in a programmable fashion.

Collaborators

Prof. Guangzhao Mao

Representative Publications

J. Blacklock, Y. Z. You, Q. H. Zhou, G. Mao, D. Oupicky. "Gene delivery in vitro and in vivo from bioreducible multilayered polyelectrolyte films of plasmid DNA." Biomaterials, 2009, 30, 939-950. (Abstract)